If we could lose our salvation, we would. From one of our Ask Ligonier events, John MacArthur invites Christians to find rest in the Savior who will never let them go.
Therefore He is able also to save forever those who draw near to God through Him, since He always lives to make intercession for them. 26 For it was fitting for us to have such a high priest, holy, innocent, undefiled, separated from sinners and exalted above the heavens; 27 who does not need daily, like those high priests, to offer up sacrifices, first for His own sins and then for the sins of the people, because this He did once for all when He offered up Himself. ~ Hebrews 7:25-27 [Emphasis Mine]
Once enrolled in the lists of this Church, sinners are safe for eternity; they are never cast away. The election of God the Father, the continual intercession of God the Son, the daily renewing and sanctifying power of God the Holy Ghost, surround and fence them in like a garden enclosed. Not one bone of Christ’s mystical Body shall ever be broken; not one lamb of Christ’s flock shall ever be plucked out of His hand.~J.C. Ryle
My sheep hear My voice, and I know them, and they follow Me;
28 and I give eternal life to them, and they will never perish;
and no one will snatch them out of My hand.